Laser-Induced Fluorescence Spectroscopy (LIF)
The WavSTAT Optical Biopsy System is presently based upon technology that detects the native fluorescence of tissue. Fluorescence occurs when various molecular components present in tissue are “excited” at certain wavelengths of light and re-emit energy in a distinct and measurable way. This re-emitted energy is referred to as the spectral signature. Healthy tissue generates a spectral signature that is measurably different from tissue that is not normal, such as cancerous and pre-cancerous tissue. LIF targets these chemical properties of tissue: amino acids, enzymes, and structural proteins.
Scattering Spectroscopy (SS)
This IP-protected technology is a novel optical scientific method that will complement our LIF technology in future WavSTAT Systems. It can be used in combination with LIF or stand-alone for diagnosis. SS targets physical properties of tissue: vascularity, epithelial thickness and cell nuclei.
SS employs a wavelength-dependent component of light scattered by epithelial cells to obtain information about subcellular structures, such as cell nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs*. These can be optically accessed either directly or by means of optical fibers. Therefore, SS facilitates the ability to scan the tissue and detect, not merely diagnose, possible cancerous lesions.
*Citable URI: http://hdl.handle.net/1721.1/29892
In the future, we envision a combination of LIF and SS will provide a blend of light-based diagnoses for optimal clinical results across many different kinds of cancer. We believe that this “multi-modal” future will allow us to pursue many detection and diagnosis markets, with an increased number of possible strat